ABSTRACT
Microbial production of L-lysine has been reviewed with 251 references. The review includes different lysine producing microorganisms, their optimum cultural conditions, yield, assay and process of product recovery. It includes a discussion on the pathway of aspartate family of amino acid's biosynthesis in bacteria and its regulation. Achievements in this regard made through genetic engineering have also been included.
Subject(s)
Bacteria/metabolism , Fermentation , Fungi/metabolism , Lysine/biosynthesisABSTRACT
Microbial production of L-tyrosine by direct fermentation and by enzymatic methods has been reviewed. Achievements in this regard made through recombinant DNA techniques have also been included. The review also includes biosynthesis and regulation of tyrosine.
Subject(s)
Bacillus subtilis/genetics , Carbon/metabolism , DNA, Recombinant/genetics , Enzymes/chemistry , Escherichia coli/genetics , Fermentation , Mutation/genetics , Stereoisomerism , Tyrosine/biosynthesisABSTRACT
Microbial production of L-tryptophan has been reviewed with 172 references. The review includes different tryptophan producing microorganisms, their optimal cultural conditions, yields, assay and process of recovery. It also includes a discussion on the pathway of tryptophan biosynthesis and its regulation. Achievements in this regard made through genetic engineering have also been included.
Subject(s)
Bacteria/metabolism , Fungi/metabolism , Tryptophan/biosynthesisABSTRACT
Microbial production of L-phenylalanine by direct fermentation and by substrate conversion has been reviewed. The review also includes a discussion on different other methods for phenylalanine production, their advantages and disadvantages with mutants and genetically tailored strains. Biosynthesis of phenylalanine, its regulation in hyperproducing strains and recovery of phenylalanine has been discussed in brief.